Research Portfolio
Learn about completed and ongoing projects with the Neuro Omics Core
Spatial Profiling of Normal-Appearing White Matter in Multiple Sclerosis - Dr. Carlos Camara-Lemarroy
Visium HD
This study investigates molecular changes in the normal-appearing white matter of people with multiple sclerosis by comparing it to healthy control tissue. Visium HD will reveal spatial patterns of gene expression that may provide new insights into disease-associated pathways and cellular changes beyond visible lesion pathology.
Remote Ischemic Conditioning in ALS - Dr. Carlos Camara-Lemarroy
Visium HD
This study explores how remote ischemic conditioning influences the molecular response to amyotrophic lateral sclerosis in the SOD1-G93A mouse model. Visium HD will map spatial gene expression within the spinal cord to identify pathways associated with neurodegeneration, neuroinflammation, and potential neuroprotective responses to treatment.
Remote Ischemic Conditioning in Repeated Mild Brain Injury - Aly Muhammad Salim
Visium HD
Researchers are examining how remote ischemic conditioning alters the molecular response to repeated mild traumatic brain injury. Visium HD will provide spatial gene expression data to identify pathways associated with neuroinflammation, tissue repair, and functional recovery
Molecular Profiling of distinct Multiple Sclerosis Lesion types - Dr. Rianne Gorter
Visium HD
The aim is to characterize molecular differences between distinct multiple sclerosis lesion types in human brain tissue. Visium HD will provide spatial gene expression data to identify biological pathways associated with lesion pathology and disease progression.
Immune Cell Trafficking in EAE - Dr. Maryam Mobarakabadi
Visium HD
The aim is to determine how a targeted genetic knockout affects immune cell trafficking within lymph nodes in an EAE mouse model of multiple sclerosis, with a focus on the role of extracellular matrix proteins. Visium HD will provide spatial gene expression data to identify the molecular mechanisms underlying changes in immune cell localization and migration.
Blood-Brain Barrier Dysfunction in Multiple Sclerosis - Yohan Zonta
Visium HD
We have shown that Cystatin C expression in astrocytes promotes multiple sclerosis (MS)-like disease in females but not males in a model of the disease; Cystatin C expression is increased in the brains of people with MS. To elucidate the mechanism underlying the sex difference, our data thus far indicates that Cystatin C in astrocytes promotes leakiness of the blood brain barrier (BBB) in females. The goal of the Visium HD platform experiment is to identify the molecular players, if any, that drive permeability of the BBB in females by analyzing the interface between astrocytes and endothelial cells.
Neurotoxic Mechanisms in Demyelinating Lesions - Dr. Atefeh Rayatpour
Visium HD
This study explores how a newly recognized neurotoxic protein contributes to demyelination and neurodegeneration in a focal spinal cord lesion model. Visium HD will map gene expression across the lesion and surrounding tissue to uncover the molecular pathways driving neuroinflammation and tissue injury