publications

Publications

Single Cell and Spatial Transcriptomics publications

  1. Randhawa G, Mobarakabadi M, D'Mello C, Morch MT, Zhang P, Ling CC, Yong VW, Ghorbani S. Targeting extracellular matrix components to attenuate microglia neuroinflammation: A study of fibulin-2 and CSPGs in a model of multiple sclerosis. J Neuroimmunol. 2025 Jan 22;400:578533
  2. Ghorbani S, Li C, Lozinski BM, Moezzi D, D’Mello C, Dong Y, Visser F, Li H, Silva C, Khakpour M, Murray CJ, Tremblay ME, Xue M, Yong VW. Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis, J Clin Invest., 2024; 134(13): e176910
  3. Stephenson E, William RJ, Ghorbani S, Gorter RP, D’Mello C, Yong VW.  Uncovering novel extracellular matrix transcriptome alterations in lesions of multiple sclerosis, Int J Mol Sci., 2024; 25(2):1240
  4. Xue S, Lozinski BM, Ghorbani S, Ta K, D'Mello C, Yong VW, Dong Y. Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration. J Neurosci. 2023 Jun 21;43(25):4725-4737.
  5. Mirzaei R, D’Mello C, Liu M, Nikolic A, Kumar M, Visser F, Bose P, Gallo M, Yong VW. Single-cell spatial analysis identifies regulators of brain tumor initiating cells, Cancer Res 83:1725-1741, 2023
  6. Dong Y, Jain RW, D’Mello C, Lozinski B, Visser F, Ghorbani S, Zandee S, Brown DI, Prat A, Xue M, Yong VW, Single cell and spatial RNA sequencing identify perturbators of microglia functions with ageing, Nature Aging 2:508-525, 2022
  7. Dong Y, D’Mello C, Moezzi D, Lozinski B, Kaushik D, Ghorbanigazar S, Brown D, Melo FC, Vo T, Yong VW, Oxidized phosphatidylcholines in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia, Nature Neuroscience 24:489-503, 2021
  8. De Boeck A*, Ahn BY*, D'Mello C, Lun X, Menon SV, Alshehri MM, Szulzewsky F, Shen Y, Khan L, Dang NH, Reichardt E, Goring KA, King J, Grisdale CJ, Grinshtein N, Hambardzumyan D, Reilly KM, Blough MD, Cairncross JG, Yong VW, Marra MA, Jones SJM, Kaplan DR, McCoy KD, Holland EC, Bose P, Chan JA, Robbins SM, Senger DL. Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression. Nat Commun. 2020 Oct 5;11(1):4997 *shared co-authorship