Stephanie Borgland

Professor

Physiology & Pharmacology

Psychiatry

Full Member

Hotchkiss Brain Institute

Ph.D. (Doctor of Philosophy)

M.Sc. (Master of Science)


Contact information

Phone

Office: 403.220.6967

Location

Office : HSC2107

Research and teaching

Research areas

  • Mental Health
  • obesity
  • Addiction
  • disorders of appetitive motivation
  • Stress

Research activities

My research interfaces cellular physiology, pharmacology, and behavior, with the goal of understanding and treating disorders of appetitive motivation such as obesity and addiction. Neuropeptides play a critical role in a number of homeostatic processes, including satiety, sleep/wake cycles, mood regulation, and response to stress. However, chronic drug taking can usurp these normal regulatory processes and profoundly alter motivational behaviour.

The main goal of my research is to understand how synaptic plasticity is modulated by these peptides in brain regions relevant to reward and compulsion, and to understand the behavioral consequences of neuropeptide signaling in both naïve and drug exposed animals.

My lab uses brain slice electrophysiology to elucidate the synaptic and cellular events involved in plasticity of excitatory synapses in ventral tegmental area dopamine neurons from acute animals or animals that have undergone a behavioural paradigm. We also employ immunohistochemistry techniques such as using retrograde labels as well as optogenetics to answer questions related to neural circuitry underlying the physiological effects. Use of these techniques together build a powerful arsenal for answering questions related to obesity and adaptations to drugs of abuse.


Publications

PubMed