S. R. Wayne Chen

Professor

Physiology & Pharmacology

Full Member

Hotchkiss Brain Institute

B.Sc. (Bachelor of Science)

PhD - Biochemistry


Contact information

Phone

Office: 403.220.4235

Location

Office : HRICGAC58

Preferred method of communication

Administrative Assistant:
Hollis Fraser
E: hollis.fraser@ucalgary.ca
Ph: 403-220-3757


Research and teaching

Research areas

  • Dementia & Cognitive Disorders
  • cardiac arrhythmia
  • RyR2 dysfunction
  • Alzheimer’s disease

Research activities

We are interested in the structure, function, and regulation of intracellular calcium release channels (ryanodine receptors, RyRs, and inositol 1,4,5-trisphosphate receptors, ITPRs), and their roles in cardiac disorders and neurodegenerative diseases. More specifically, we are currently working on (1) a new entity of cardiac arrhythmia associated with RyR2 dysfunction, (2) the role of RyR2 in the pathogenesis of Alzheimer’s disease, (3) New disease entities associated with ITPR1 and ITPR2 dysfunction, (4) high-resolution three-dimensional structures of RyRs and their structure-function relationships, and (5) the development of novel therapeutics for the treatment of cardiac arrhythmias and Alzheimer’s disease.


Biography

Affiliations: 
Libin Cardiovascular Institute of Alberta

Heart and Stroke Foundation Chair in Cardiovascular Research


Publications

PubMed


Awards

  • 2017  -  Heart and Stroke Foundation Chair in Cardiovascular Research
  • 2016  -  The James O. Davis Distinguished Lecturer and Chancellor’s Distinguished Lecturer, Dalton Cardiovascular Research Centre, University of Missouri,USA
  • 2014  -  UCalgary GREAT Graduate Student Supervisor
  • 2013  -  Keynote Speaker, Malignant Hyperthermia Association of United States Conference, Toronto, Canada
  • 2012-2018  -  Heart and Stroke Foundation/Libin Professorship in Cardiovascular Research, University of Calgary
  • 2011  -  Keynote Speaker, XIX International Society for Heart Research (ISHR) Congress, Latin American Section, Buenos Aires, Argentina
  • 2010-2017  -  Scientist, Alberta Innovates-Health Solutions (AIHS)
  • 2010-2017  -  Research Prize, Alberta Innovates-Health Solutions (AIHS)
  • 2009  -  Leaders Opportunity Fund Award (Canada Foundation for Innovation (CFI)
  • 2005-2010  -  Scientist, Alberta Heritage Foundation for Medical Research
  • 2005-2010  -  Research Prize, Alberta Heritage Foundation for Medical Research
  • 2008  -  Distinguished Cardiovascular Lecture, Departments of Physiology and Medicine, University of California, Los Angeles, USA
  • 2005  -  Keynote Speaker, the 24th Meeting of the Coronary Club, Sendai, Japan
  • 2005  -  Leica Associate Professor Award, Department of Biochemistry and Molecular Biology, University of Calgary
  • 2003  -  Cochrane Distinguished Achievement Award for Excellence in Research, Faculty of Medicine, University of Calgary
  • 2002  -  Cochrane Distinguished Achievement Award for Excellence in Research, Faculty of Medicine, University of Calgary
  • 2000-2005  -  Senior Scholar, Alberta Heritage Foundation for Medical Research