Ph.D. (Doctor of Philosophy)
Research and teaching
Ion channel interactions in neural circuit function. We examine the nature of interactions between ion channels at the molecular and physiological levels, with an emphasis on calcium and potassium channels that are coupled to control cell excitability. Recent work has focused on the role for a T-type calcium / A-type potassium channel complex that underlies long-term potentiation in the cerebellum, and the ability to restore this function using a newly developed therapeutic to treat Fragile X Syndrome, the leading genetic cause of autism spectrum disorders. A second project focuses on how the molecular organization of ion channels at the membrane drives inhibitory responses in hippocampal pyramidal cells. For this work we use a combination of electrophysiology, molecular biology, immunocytochemistry with super-resolution microscopy, and behavioural tests.