Ph.D. (Doctor of Philosophy)
Research and teaching
We have been studying leukocyte/endothelial cell interactions in vivo using intravital microscopy. Our primary focus is to understand leukocyte recruitment in various models of inflammatory disease in various tissues. We use currently available molecular tools to assess the importance of adhesion molecules and associated proteins including mutant mice missing the gene(s) for certain proteins involved in the leukocyte recruitment cascade. Migration via the vasculature in MS, concussion and encephalopathy are key areas. We use spinning disk and two photon microscopy but we are now interested in combining this with understanding neural regulation of immunity.