Jeffrey T Joseph


Pathology & Laboratory Medicine

Full Member

Hotchkiss Brain Institute

M.D. (Doctor of Medicine)

Contact information


Office: 403.944.8849


Office : FMCC1146

Research and teaching

Research areas

  • Dementia & Cognitive Disorders
  • Movement Disorders

Research activities

In my graduate student research, I discovered and characterized the mitochondrial genome from the malaria parasite. My remaining research has been in clinical neuropathology. I have worked on brain tumours, progressive multifocal leukoencephalopathy (JC virus), select muscle diseases, select areas of forensic neuropathology, several neurodegenerative diseases, developmental diseases (Wolfram syndrome, pontocerebellar hypoplasia), and Creutzfeldt-Jacob disease. I have done some work detailing the mathematical limitations of mitotic counts in grading brain tumours. I am currently working with Peter Stys on characterizing amyloid and tau deposition in Alzheimer disease using small beta-sheet-specific dyes. 

I have taught medical students neuroanatomy, both at Harvard Medical School (head of laboratory sessions) and the University of Calgary. I recently organized and taught neuroanatomy to graduate students in Medical Science at the university of Calgary (MDSC 751.42). I also teach neuropathology extensively to residents in neuropathology, neurology, neurosurgery, and paediatric neurology.

My professional interests are in all aspects of neuropathology as well as running and maintaining a progressive neuropathology clinical service. I have also been banking autopsy brain tissue for specific researchers.