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Dr. Stephanie Borgland

Position: 

Associate Professor, Physiology & Pharmacology

Phone: 
(403) 220-6967
Address: 

Office: HSC 2107
Lab: HSC 2077, 2074, 2075
University of Calgary 3330 Hospital Drive NW Calgary, AB T2N 4N1

Research Activities: 

My research interfaces cellular physiology, pharmacology, and behavior, with the goal of understanding and treating disorders of appetitive motivation such as obesity and addiction. Neuropeptides play a critical role in a number of homeostatic processes, including satiety, sleep/wake cycles, mood regulation, and response to stress. However, chronic drug taking can usurp these normal regulatory processes and profoundly alter motivational behaviour.

The main goal of my research is to understand how synaptic plasticity is modulated by these peptides in brain regions relevant to reward and compulsion, and to understand the behavioral consequences of neuropeptide signaling in both naïve and drug exposed animals.

My lab uses brain slice electrophysiology to elucidate the synaptic and cellular events involved in plasticity of excitatory synapses in ventral tegmental area dopamine neurons from acute animals or animals that have undergone a behavioural paradigm. We also employ immunohistochemistry techniques such as using retrograde labels as well as optogenetics to answer questions related to neural circuitry underlying the physiological effects. Use of these techniques together build a powerful arsenal for answering questions related to obesity and adaptations to drugs of abuse.
Research Funding

  • CIHR New Investigator Award
  • CIHR
  • NSERC
  • CFI
Research Areas: 
disorders of appetitive motivation
obesity
Addiction
Research Interests: 
Publications: 
Degrees: 
  • Ph.D. (Doctor of Philosophy)
  • M.Sc. (Master of Science)
Research Personnel: