The Hotchkiss Brain Institute
Healthy Brains for Better Lives
Professor, Physiology & Pharmacology
University of Calgary
Office: HSC 2213
Lab: HSC 2077
University of Calgary
3330 Hospital Drive N.W.
Calgary, AB T2N 4N1
The focus of our lab is to bring together two large and important areas of neuroscience: the study of stress and the study of synapses.
Our goal is to think about stress from a synaptic perspective first. Using this approach, we hope to provide new information that will do three things:
Using techniques that allow us to probe brain function from single synapses to awake, behaving animals, our goal is to understand how physiological and psychological challenges lead to long-term changes in the brain. We focus on neurons in the hypothalamus that coordinate the mammalian response to stress, with a particular interest in how the molecules, or neuromodulators released at the onset of a stress leave a lasting imprint to alter subsequent stress responses.
Experience salience gates endocannabinoid signaling at hypothalamic synapses. J.I. Wamsteeker Cusulin, L. Senst, G.C. Teskey and J.S. Bains, Journal of Neuroscience, Apr 30;34(18):6177-81, 2014.
Noradrenaline is a stress-associated metaplastic signal at GABA synapses, W. Inoue, D. V. Baimoukhametova, T. Füzesi, J.I. Wamsteeker Cusulin, K. Koblinger, P. J. Whelan, Q. J. Pittman and J. S. Bains, Nature Neuroscience, May;16(5):605-12, 2013.
Glucocorticoid feedback uncovers retrograde opioid signaling at hypothalamic synapses, J.I. Wamsteeker Cusulin, T. Füzesi, W. Inoue and J.S. Bains, Nature Neuroscience, May;16(5):596-604, 2013.
Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits, K.M. Crosby, W.I. Inoue, Q.J. Pittman and J.S. Bains, Neuron, Aug 11;71(3):529-41, 2011.
Stress induced priming of glutamate synapses unmasks associative short-term plasticity, J.B. Kuzmiski, V.M. Marty, D.V. Baimoukhametova and J.S. Bains, Nature Neuroscience, Oct;13(10):1257-1264, 2010.
Astrocyte mediated distributed plasticity at hypothalamic glutamate synapses, G.R.J. Gordon, K.J. Iremonger, S. Kantevari, G.C. Ellis-Davies, B.A. MacVicar and J.S. Bains, Neuron, Nov;64(3):391-403, 2009.
Metaplasticity of hypothalamic synapses following in vivo challenge, J.B. Kuzmiski, Q.J. Pittman and J.S. Bains, Neuron, June;62(6):839-849, 2009.
Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis, S.A. Hewitt, J.I. Wamsteeker, E.U. Kurz and J.S. Bains, Nature Neuroscience, Apr;12(4):438-443, 2009.
Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy, G.R.J. Gordon, D.V. Baimoukhametova, S.A. Hewitt, W.R. Rajapaksha, T.E. Fisher and J.S. Bains, Nature Neuroscience, Aug;8(8):1078-1086, 2005.